Clinical Fact Finder

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+ Pain

Indication
Title
Cannabinoids
Type
Patients
Year
Open Source
Chronic/Neuropathic Pain
Medical Cannabis for Neuropathic Pain
THC (plant)
Systematic Review
N/A
2018
Chronic/Neuropathic Pain
Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases
THC, THC:CBD
Systematic Review
N/A
2018
Chronic/Neuropathic Pain
Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
THC, CBD, Nabilone, Dronabinol, THC:CBD
Systematic Review
1,334
2017
Chronic/Neuropathic Pain
Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials
THC, THC (plant), Nabilone, Dronabinol, THC-11-oic Acid
Systematic Review
766
2011
Chronic/Neuropathic Pain
Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain
THC (plant)
DB, PC, CO
39
2013
Chronic/Neuropathic Pain
Smoked cannabis for chronic neuropathic pain: a randomized controlled trial
THC (plant)
R, DB, PC, CO
21
2010
Chronic/Neuropathic Pain
Efficacy of Dronabinol as an Adjuvant Treatment for Chronic Pain Patients on Opioid Therapy
Dronabinol
R, DB, PC, CO, Phase 1
30
2008
Chronic/Neuropathic Pain
A Randomized, Placebo-Controlled, Crossover Trial of Cannabis Cigarettes in Neuropathic Pain
THC (plant)
DB, PC, CO
38
2008
Chronic/Neuropathic Pain
Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies
THC, CBD, THC:CBD
R, DB, PC, CO
34
2004
Chronic/Neuropathic Pain
Topical cannabidiol is well tolerated in individuals with a history of elite physical performance and chronic lower extremity pain
CBD
Pilot Study
20
2023
Chronic/Neuropathic Pain
Comparing the effects of medical cannabis for chronic pain patients with and without co-morbid anxiety: A cohort study
THC, CBD
Observational Study, Prospective Cohort Study
1,254
2023
Chronic/Neuropathic Pain
Medical Cannabis Used as an Alternative Treatment for Chronic Pain Demonstrates Reduction in Chronic Opioid Use – A Prospective Study
Single Centre Prospective Study
115
2022
Chronic/Neuropathic Pain
Health Outcomes among Adults Initiating Medical Cannabis for Chronic Pain: A 3-month Prospective Study Incorporating Ecological Momentary Assessment (EMA)
THC, CBD, THC/CBD
Prospective Cohort Study
46
2021
Chronic/Neuropathic Pain
Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis
THC, CBD, Dronabinol
PC, Review
861
2021
Chronic/Neuropathic Pain
Matched pilot study examining cannabis-based dronabinol for acute pain following traumatic injury
Dronabinol
66
2020
Chronic/Neuropathic Pain
Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease: A Randomized Clinical Trial
THC+CBD, THC/CBD, THC:CBD
Clinical Trial
23
2020
Chronic/Neuropathic Pain
Effects of cannabinoid administration for pain
THC
Meta-Analysis
N/A
2019
Chronic/Neuropathic Pain
Effectiveness of THC:CBD oromucosal spray in patients with chronic pain
THC+CBD, THC/CBD, THC:CBD
Review
1,310
2019
Chronic/Neuropathic Pain
Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial
CBD
R, DB
60
2019
Chronic/Neuropathic Pain
A Study to Evaluate the Effects of Cannabis Based Medicine in Patients With Pain of Neurological Origin
THC:CBD
Clinical Trial
70
2012
Fibromyalgia
An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia
THC, CBD, THC:CBD
R, DB, PC, CO
20
2019
Fibromyalgia
Safety and Efficacy of Medical Cannabis in Fibromyalgia
THC, CBD
Observational Study
211
2019
Fibromyalgia
Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
THC
R, DB, PC, Clinical Trial
18
2020
IBD
Medical Cannabis: An Option for the Treatment of IBD & Colon Cancer?
THC, CBD, THC/CBD
Review
N/A
2018
IBD
Cannabis Induces a Clinical Response in Patients With Crohn’s Disease: A Prospective Placebo-Controlled Study
THC
PC, Prospective Cohort Study
21
2013
Multiple
Role of the cannabinoid system in pain control
THC/CBD
Mode of Action
N/A
2006

+ Palliative Care

Indication
Title
Cannabinoids
Type
Patients
Year
Open Source
Cancer
Cannabis and Cannabinoids (PDQ®)–Health Professional Version (National Cancer Institute)
THC, CBD, Dronabinol, THC:CBD
Systematic Review
N/A
2020
Cancer
Efficacy, tolerability and safety of cannabis-based medicines for cancer pain
THC, THC:CBD
Systematic Review
N/A
2019
Cancer
Prospects for the Use of Cannabinoids in Oncology and Palliative Care Practice: A Review of the Evidence
THC, CBD, THC:CBD
Systematic Review
N/A
2019
Cancer
Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain
THC:CBD, Nabiximols
R, DB, PC, Phase 3
397
2018
Cancer
Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial
Nabiximols
R, DB, PC
263
2012
Cancer
Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain
THC, THC:CBD
R, DB, PC, PG
177
2010
Cancer
Nabilone Versus Prochlorperazine for Control of Cancer Chemotherapy-Induced Emesis in Children: A Double-Blind, Crossover Trial
Nabilone
R, DB, CO
30
1987
General
Cannabis in palliative care: current challenges and practical recommendations
THC, CBD, Dronabinol, THC:CBD
Systematic Review
N/A
2018
HIV
Smoked Medicinal Cannabis for Neuropathic Pain in HIV: A Randomized, Crossover Clinical Trial
THC (plant)
DB, PC, CO, Phase 2
N/A
2009
HIV
Cannabis in painful HIV-associated sensory neuropathy
THC
R, PC
50
2007
Summaries
Cannabidiol prescription in clinical practice: an audit on the first 400 patients in New Zealand
CBD
Review
400
2020
Summaries
Therapeutic Effects of Cannabis and Cannabinoids
THC, CBD, THC/CBD
Review
N/A
2017

+ Neurological

Indication
Title
Cannabinoids
Type
Patients
Year
Open Source
Anxiety
Effects of Marijuana on Mental Health: Anxiety Disorders
THC, CBD, THC:CBD
Systematic Review
N/A
2017
Anxiety
CBD as a Potential Treatment for Anxiety
CBD
Systematic Review
N/A
2015
Anxiety
Dose related effects of THC on responses to psychosocial stress
THC
R, DB, PC
42
2017
Anxiety
Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
CBD
R, DB, PC
24
2011
Anxiety
Effects of ipsapirone and cannabidiol on human experimental anxiety
CBD
DB, PC
40
1993
Anxiety
Cannabidiol in Anxiety and Sleep: A Large Case Series
CBD
Retrospective Study
72
2019
Anxiety
Cannabidiol as a Potential Treatment for Anxiety Disorders
CBD
Review
N/A
2015
Dementia
Prescription of a THC/CBD-Based Medication to Patients with Dementia: A Pilot Study in Geneva
THC/CBD
Observational Study
10
2019
Epilepsy
Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials
CBD
Systematic Review
N/A
2019
Epilepsy
Efficacy and Safety of GWP42003-P for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults (GWPCARE3)
CBD
Clinical Trial Results
225
2018
Epilepsy
Cannabidiol in the Treatment of Epilepsy
CBD
Review
N/A
2021
General
Nabilone for Agitation in Alzheimer’s Disease
Nabilone
R, DB, CO
39
2020
Insomnia
Medicinal cannabis improves sleep in adults with insomnia
THC+CBD, THC/CBD, THC:CBD
R, DB, PC, CO
29
2022
Multiple Sclerosis
Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
THC
R, DB, PC, CO
30
2012
Multiple Sclerosis
Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
THC:CBD
R, DB, PC, CO
57
2004
Psychiatric Disorders
Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review
THC, CBD
Systematic Review
N/A
2020
Psychiatric Disorders
Cannabidiol as a potential treatment for psychosis
CBD
Systematic Review
N/A
2019
Psychiatric Disorders
Cannabidiol (CBD) use in psychiatric disorders: A systematic review
THC, CBD, THC:CBD
Systematic Review
N/A
2019
Psychiatric Disorders
Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis
CBD
R, DB, PC, PG, Clinical Trial
33
2018
Psychiatric Disorders
Opposite Effects of THC and CBD on Brain Function and Psychopathology
THC, CBD
DB, PC
15
2009

+ Tolerability

Indication
Title
Cannabinoids
Type
Patients
Year
Open Source
Adverse Events
Adverse effects of medical cannabinoids: a systematic review
THC, CBD
Systematic Review
N/A
2008
Adverse Events
Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS)
THC (plant)
Prospective Cohort Study
431
2015
Adverse Events
Nabiximols as an Agonist Replacement Therapy During Cannabis WithdrawalA Randomized Clinical Trial
CBD:THC (Nabiximols)
R, DB, PC, Clinical Trial
51
2014
Adverse Events
Medicinal Cannabis – Potential Drug Interactions
THC, CBD
Review
N/A
2018
Driving Impairment
Cannabis Effects on Driving Skills
THC
Review
N/A
2014
Drug-drug interactions
Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use
CBD
Summary
N/A
2019
Pregnancy
Cannabis Abuse or Dependence During Pregnancy: A Population-Based Cohort Study on 12 Million Births
THC
RS
12.5m
2018
Pregnancy
Effects of Maternal Marijuana and Cocaine Use on Fetal Growth
THC
PS
1,226
1989

+ Health Agency Reviews

Agency
Title
Cannabinoids
Type
Patients
Year
Open Source
Canada
Information for Health Care Professionals: Cannabis (marihuana, marijuana) and the cannabinoids
THC, CBD
Position Paper
N/A
2018
Chronic/Neuropathic Pain
The Role of Medicinal Cannabis in Clinical Therapy: Pharmacists’ Perspectives
THC, CBD
Position Paper
N/A
2016
Europe
European Pain Federation (EFIC) position paper on appropriate use of cannabis‐based medicines and medical cannabis for chronic pain management
THC, CBD
Position Paper
N/A
2018
Referenced by Medsafe
Cannabis: The Evidence for Medical Use
THC, CBD, Dronabinol, THC:CBD
Position Paper
N/A
2016

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